Nagalase Test, Cancer Biomarker

Nagalase Test – Cancer Biomaker is test for monitoring the effect of the any cancer therapy and certain viral infections, including HIV & Autism. The test measures the activity of  alpha-N-acetylgalactosaminidase (nagalase) in blood.  Nagalase is an extracellular matrix-degrading enzyme that is (increased) secreted by cancer cells in the process of tumour invasion. It also is an intrisic component of envelope protein of various virions, such as  HIV and  the influenza virus.

A healthy level of Nagalase is below 0.62 nmol/min/mg. 

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Nagalase test as a cancer biomarker

Increased activity of nagalase has been detected in the blood of patients with  a wide variety of cancers, like cancer of the prostate, breast, colon, lung, oesophagus, stomach, liver, pancreas, kidney, bladder, testis, uterus and ovary, mesothelioma, melanoma, fibrosarcoma, glioblastoma, neuroblastoma and various leukeamias. For various types of tumors various levels of nagalase activity were found. It seems likely that secretory capacity of individual tumor tissue varies among tumor types depending upon tumor size, staging, and the degree of malignancy or invasiveness. Increased nagalase activity has not been detected in the blood of healthy humans.

Nagalase test as cancer biomarker, is a sensitive test for monitoring the effect of therapy in cancer and certain viral infections, including HIV infection. Because of the short half-life of nagalase, the method is suitable for monitoring various types of therapy. The great sensitivity of the test may help the physician / oncologist in obtaining a better understanding of the therapy and to fine-tune the treatment.

We recomend to order this test so we can determine the effectiveness of every therapy used and therefore the convenience to continue with the best therapies possible to be carried out in the future for that patient and the rest of them with the same or similar health conditions.

You can order it through us or visit our partner laboratory website HERE

If you have an illness and want us to study your case, fill out our medical form with a brief explanation of your case.